As to the remaining patient and tumor characteristics, only the positive HER2 RS in BM (median OS 23.5 vs 13.5 months, p = 0.017) and favorable preoperative KPS scale (≥ 80%, median OS 22.00 vs 7.00 months, p = 0.001) showed significant associations with OS (see supplementary table 3). This evidence concerns the gene ERBB2 and neoplasm.