Taking into account the recently published data describing the transition between two structural forms affected by N-glycosylation of SARS-CoV-2 spike protein regulating interaction with the angiotensin-converting enzyme 2 receptor (ACE2) in specific positions, we can speculate that ORNs functionalized by D-mannitol can present activity against the COVID-19-CoV-2 pandemic virus [32]. This evidence concerns the gene ACE2 and COVID-19.