Additionally, the hepatoprotective effects of ATX in liver injury were due to suppression of STAT3 activity in ethanol-induced hepatic damage [224], modulation of gut microbiota [225], inhibition of MAPK pathway activation in acetaminophen-induced hepatic injury [226], and suppression of NF-κB and autophagy in carbon tetrachloride-induced hepatic fibrosis [227] or arsenic-stimulated liver damage [228]. This evidence concerns the gene NFKB1 and Hepatic fibrosis.