PROS1 and Hodgkins lymphoma: In relation to B cell malignancies, FX and fucoxanthinol exhibited antiproliferative and proapoptotic effects in Burkitt’s and Hodgkin’s lymphoma cell lines through NF-κB activation with the consequent down-regulation of antiapoptotic proteins (Bcl-2 and X-linked inhibitor of apoptosis protein), and cell cycle regulatory proteins (cyclins D1 and D2) [471].