INS and obesity due to melanocortin 4 receptor deficiency: In brief, liver-specific mIndy RNAi silencing prevents diet-induced NAFLD in mice [40]; mINDY-KO mice are protected from age- and diet-induced insulin insensitivity and obesity; while antisense oligonucleotides given to rats on a high-fat diet prevent hepatic steatosis and hepatic insulin resistance [39].