INS and Hyperglycemia: The first cluster included four susceptibility loci having effects on insulin sensitivity; the second cluster had two susceptibility loci having effects on decreased insulin secretion and fasting hyperglycemia; the third cluster had one susceptibility locus having effects on insulin processing; the fourth cluster included five susceptibility loci having effects on insulin processing and secretion; and the fifth cluster included 20 susceptibility loci with no clear-cut associations with glycemic traits [94].