CRP and appendicitis: While there are many studies related to pediatric appendicitis diagnostic strategies including clinical scoring systems (e.g., Alvarado Score, Pediatric Appendicitis Score) [9,10,11], traditional laboratory tests of infection and inflammation (i.e., white blood cell count, erythrocyte sedimentation rate, C-reactive protein) [12,13,14,15] and imaging studies [16,17,18,19], there are obvious knowledge gaps related to our ability to accurately diagnose appendicitis and predict disease progression.