Most recently, the 5-year follow-up data from the KEYNOTE-024 clinical trial showed a median OS (overall survival) of 26.3 months for Programmed Death-Ligand 1 (PD-L1) positive NSCLC patients treated with first-line pembrolizumab, with almost a third of the pembrolizumab group still alive at the 5-year mark [4]. This evidence concerns the gene CD274 and non-small cell lung carcinoma.