VEGFA and hepatocellular carcinoma: In the field of HCC, combination therapy with anti-programmed death-ligand 1 monoclonal antibody atezolizumab plus anti-vascular endothelial growth factor (VEGF) agent bevacizumab (Atezo/Bev) was approved as a first line regimen for unresectable HCC in 2020 based on the randomized IMbrave150 clinical trial.