Adoptive cell therapy is the transfer of chimeric antigen receptor T cells (CAR-T) directed against common antigens such as DLL3 highly expressed in SCLC, with AMG 119 being a DLL3 CAR-T cell tested in SCLC [51]; however, the trial is currently suspended, and recent results from ASCO 2021 show remarkable responses with DLL3-targeted bispecific T-cell engager AMG 757 Tarlatamab [60], that is also being tested in combination with PD-1 inhibition (AMG 404) [62]. Here, DLL3 is linked to small cell lung carcinoma.