Results showed an ORR of 18.7% for the entire population compared to 35.7% for PD-L1 positive tumors, with a mPFS of two months and a mOS of 9.1 months in the entire population, whereas results were of 2.1 and 14.6 months, respectively, in PD-L1 positive patients, suggesting benefit of immunotherapy in the second line and beyond treatment of ES-SCLC. The gene discussed is CD274; the disease is small cell lung carcinoma.