GRM7 and epilepsy: As shown in Figure 5, the total mGluR7 was downregulated in the hippocampus (Figure 5A) and temporal cortex (Figure 5B) of the epilepsy group, and statistical analyses confirmed these results (p = 0.013; Figure 5C; p = 0.002; Figure 5D), which were consistent with earlier studies.37, 38