Prognosis of the HCC patients was obviously correlated with tumor size (p = 0.011), differentiation degree (p = 0.047), lymph node metastasis (p = 0.004), vascular invasion (p = 0.0001), metastasis (p = 0.003), and DHX9 expression level (p = 0.032) in univariate analysis. Here, DHX9 is linked to hepatocellular carcinoma.