TNFRSF4 and non-small cell lung carcinoma: Interestingly, CTX alone induced Tregs that showed increased expression of tumor necrosis factor receptor superfamily members, Tnfrsf4 (OX40), Tnfrsf9 (4-1BB), Tnfrsf18 (GITR), and inducible T cell costimulatory molecule, which were recently described as activated Tregs that are selectively associated with poor outcomes in non-small cell lung cancer (44).