TT-10–NP administration also promoted angiogenesis in the peri-infarct region, which (to our knowledge) has not been previously reported, and Yap/TAZ signaling can be activated by hypoxia in some cancers (14, 15), as well as extracellular matrix proteins (e.g., periostin; ref. 16), growth factors (17, 18), and microRNAs (19, 20), all of which have been linked to cardiomyocyte cell cycle activity during development or under disease conditions. Here, POSTN is linked to cancer.