These results suggest that obesity can increase ATM Ant2 expression not only by increasing the proportion of Ant2-high-expressing ATM subsets (Cd9+ and Itgax+ ATMs) but also by increasing Ant2 expression in Ant2-low-expressing ATMs (Itgax–, Lyve1+, and Cd163+ ATMs). Here, SLC25A5 is linked to obesity due to melanocortin 4 receptor deficiency.