PLAC8 and obesity due to melanocortin 4 receptor deficiency: Consistent with previous reports, obesity enhanced the proportion of Itgax+ (encoding CD11c) and Cd9+ ATMs (cluster 0) and Plac8+ monocytes (cluster 4) and reduced the proportion of Lyve1+ and Cd163+ ATMs (cluster 1) and Lyz1+ monocytes (Supplemental Figure 3, I–K) (61–63).