Although exactly how obesity induces proinflammatory ATM activation is not yet clearly understood, several lines of evidence indicate that increased free fatty acid (FFA) levels play a key role in this process by activating cell-surface Toll-like receptor 2 (TLR2) and TLR4 or altering lipid metabolism (9, 25–32). Here, TLR2 is linked to obesity due to melanocortin 4 receptor deficiency.