ACE and autosomal dominant polycystic kidney disease: Hyperactivation of the sympathetic system has been reported in patients affected by ADPKD (Klein et al., 2001) and a key role for this activation is suggested by two common clinical practices: treatment of patients with angiotensin‐converting enzyme inhibitors/angiotensin II receptor blockers to control their blood pressure and renal denervation to treat kidney‐related pain (Tellman et al., 2015; Tkachenko et al., 2013).