CDKN1A and thyroid gland carcinoma: In terms of gene products most frequently targeted by the differentially expressed miRNAs, the top 30 most affected validated genes included MDM2, CDK6, DICER1, CCND1 (encoding cyclin D1), and CDKN1A (encoding p21), all exhibiting some association to the development or progression of thyroid cancer (Table 1).