Conversely, an in vivo human study, using the hyperinsulinemic–euglycemic clamp, showed that hyperinsulinemia did not increase β-alanine uptake when substrate concentrations exceeded the Vmax of TauT nor when it was below saturation of the β-alanine transporters (Goncalves et al. 2020). This evidence concerns the gene SLC6A6 and hyperinsulinism.