These results suggest that RPS14/uS11 haploinsufficiency in the 5q-syndrome (Ebert et al., 2008) and frequent RPL22/eL22 hemizygous gene deletions found in cancer (Ajore et al., 2017) could play a role in proteome diversity and tumorigenesis. The gene discussed is RPL22; the disease is myelodysplastic syndrome associated with isolated del(5q).