We used a multiple step regression to analyze the relationships between TNF-α, RHI, and AIx75 and age, BMI, AHI, AI, PSG parameters (mean SpO2, LSpO2, T90, percentages in stages N1, N2, N3, REM, and wake), and cardiovascular risk factors (smoking, hypertension, blood glucose, HbA1C, TC, TG, HDL, and LDLC). This evidence concerns the gene TNF and Hypertension.