Moreover, it has been claimed that the tumor suppressor activity of MT1H depends on its ability to interact and to promote histone methyltransferase activity of euchromatin histone methyltransferase 1 (EHMT1) involved in the carcinogenesis of prostate cancer, which remains to be discussed in those with HCC (Han et al., 2013). This evidence concerns the gene PRDM9 and hepatocellular carcinoma.