TNF and neoplasm: Intriguingly, KEGG enrichment analysis defined functional-associated pathways of the genes co-expressed with MT1H, among which hsa04064 (NF-kappa B signaling pathway), hsa04630 (Jak–STAT signaling pathway), hsa04620 (Toll-like receptor signaling pathway), and hsa04668 (TNF signaling pathway) were involved in tumor growth and progression (Figure 7D).