The main transcription factor controlling liver fatty acid metabolism, sterol regulatory element-binding protein 1 (SREBP-1), which is elevated in the NASH can be decreased by either 12-week aerobic exercise of high intensity or resistance training through the increase of AMPK, leading to reduction of de novo lipogenesis in hepatocytes (26, 27). The gene discussed is SREBF1; the disease is metabolic dysfunction-associated steatohepatitis.