In this cohort, we only identified four male patients carrying a LHON-mtDNA mutation, and this rate (8.5%) was much lower than the rate (38.3%) in patients harboring OPA1 mutations and the rate (33%) in Chinese patients with LHON or suspected with LHON (Ji et al., 2008; Yu et al., 2010). Here, OPA1 is linked to Leber hereditary optic neuropathy.