For example, TNFSF12-TNFRSF12A and SPP1-CD44 were shown in LC, CRC, and SCC (Figure 4A and Supplementary Figure 5), indicating that myeloid cells might express and secrete TNFSF12 and SPP1, signaling to their receptors TNFRSF12A and CD44 on cancer cells, respectively. This evidence concerns the gene SPP1 and cancer.