Although in the work of Yu et al. (2012), MARVELD1 was down-regulated in HCC tissues, and high expression of MARVELD1 suppressed proliferation and enhanced chemosensitivity of HCC cells, our results showed that there was no significant differential expression of MARVELD1 in both TCGA and ICGC paired tumor and normal samples. This evidence concerns the gene MARVELD1 and hepatocellular carcinoma.