The results showed that the mRNA expressions of six genes (CST2, EPHB6, MAGEA6, PDZD4, SEMA6A, and SLCO2A1) were differentially expressed between the HCC tissues and paratumor liver tissues from the TCGA, the ICGC, and our clinical samples. The gene discussed is SLCO2A1; the disease is hepatocellular carcinoma.