TLR4 and Behcet disease: In addition, the researchers detected and analyzed the association between nine SNPs in TLR4 and BD through direct sequencing, and found that the TLR4 polymorphism may increase the risk of BD in the Japanese population (Meguro et al., 2008), which has also been confirmed in the Korean and Italian populations (Meguro et al., 2008; Boiardi et al., 2009).