Increased levels of cytokines produced by T cells, such as IL-2, IL-12, IL-18, and TNF-α, may lead to the activation of endothelial cells and neutrophils, so the inflammatory response of BD can be attributed to the excessive production of pro-inflammatory cytokines and a decrease in anti-inflammatory factors (Aziz et al., 2020). This evidence concerns the gene TNF and Behcet disease.