SUMO4 and Autoimmunity: SUMO4 participates in autoimmunity and inflammation by regulating NF-κB and activating heat shock transcription factors, resulting in the decreased transcription of proinflammatory cytokines (Hou et al., 2008), some studies have shown that SUMO4 +438 C and −847 G alleles seem to be associated with susceptibility to BD, and their gene polymorphisms may be involved in the development of skin lesions, vascular BD, as well as the severity of the disease (Kamoun et al., 2010).