Moreover, YAP1-induced autophagy plays a pivotal role to induce drug resistance in multiple cancers (Zhu et al., 2018; Wang C. Z. et al., 2019), and we expectedly evidenced that ANXA6 overexpression-induced upregulation of LC3B-II/I ratio and p62 downregulation in PTX-treated PS-BC cells were all reversed by silencing YAP1 (Figures 5H–M). The gene discussed is ANXA6; the disease is breast cancer.