Taken together, this study investigated the potential underlying mechanisms by which BCSCs regulated PTX resistance in BC and verified that BCSC-derived exosomes delivered ANXA6 to the surrounding PS-BC cells, which further activated the YAP1-associated signaling pathways and promoted cell autophagy and stemness, leading to the generation of PTX resistance in PS-BC cells. This evidence concerns the gene ANXA6 and breast cancer.