ANXA6 and cancer: Thus, in the present study, we focused on investigating whether BC cells secreted ANXA6-containing exosomes to modulate PTX resistance and cancer progression in BC, and we evidenced that PTX-resistant BC (PR-BC) cells delivered ANXA6 to PS-BC cells through secreting ANXA6-containing exosomes, which further up-regulated its downstream oncogene Yes-associated protein 1 (YAP1), leading to cancer progression and PTX resistance in BC.