Given that we had proved that ANXA6 up-regulated YAP1 to regulate cell stemness and autophagy, which were pivotal for the generation of PTX resistance in BC, and ANXA6 directly regulated PTX resistance in BC, we hypothesized that the ANXA6/YAP1 pathway was also involved in regulating PTX sensitivity in BC. This evidence concerns the gene ANXA6 and breast cancer.