We next investigated the underlying mechanisms by which ANXA6 regulated cancer progression, cell stemness, and autophagy in BC cells, and according to the existing information that ANXA6 directly induces YAP1 activation (Uchihara et al., 2020), which is reported to be closely associated with BC development (Gan et al., 2019; Lee et al., 2019), we speculated that ANXA6 might exert its tumor-promoting role through modulating the YAP1/Hippo pathway. The gene discussed is YAP1; the disease is cancer.