Further experiments evidenced that YAP1 knockdown suppressed cell migration, stemness, and autophagy in ANXA6-overexpressed PS-BC cells, and consistently, upregulation of YAP1 abrogated the inhibiting effects of ANXA6 knockdown on PTX resistance in PR-BC cells, suggesting that ANXA6 regulated the cellular functions to promote PTX resistance in BC cells through modulating YAP1. Here, ANXA6 is linked to breast cancer.