Moreover, upregulation of ANXA6 increased PTX resistance in PS-BC cells through activating autophagy flux, which were supported by previous literatures that show that blockage of autophagy is effective to increase drug sensitivity in BC (Wen et al., 2020; Sun et al., 2021; Yu et al., 2021), implying that PR-BC-derived ANXA6-containing exosomes increased PTX resistance by inducing autophagy and CSC properties. Here, ANXA6 is linked to breast cancer.