ANXA6 and cancer: Next, by searching the existing information from the online PubMed database, we noticed that one of the exosomal protein ANXA6 is closely associated with cancer progression (Kapustin and Shanahan, 2016; Keklikoglou et al., 2019) and drug resistance (Uchihara et al., 2020), and this protein also plays an important role in regulating the biological functions of BC cells during its pathogenesis (Sakwe et al., 2011; Widatalla et al., 2019; Korolkova et al., 2020).