HSCs act as a prominent player in the process of liver fibrosis because of its ability to produce fibrogenic proteins, α-SMA and CoL1A1 (Parsons et al., 2007; Friedman, 2008; Hernandez-Gea and Friedman, 2011; Parola and Pinzani, 2019). Here, COL1A1 is linked to Hepatic fibrosis.