Zhu et al. (2020) previously demonstrated that MFN2 could promote HSC apoptosis and ameliorate liver fibrosis by regulating TGF−β/Smad signaling. Herein, our study emphasized the importance of MFN2 in liver fibrosis, since that MFN2 could strongly reverse the effect of exosomal miR-500 on liver fibrosis both in vitro and in vivo. This evidence concerns the gene MFN2 and Hepatic fibrosis.