Based on a review of the literature on HPV integration sites and genomic alterations in cervical cancer (8, 15), we prepared probes targeting five regions of the human chromosome: 3p14 containing FHIT, 8q24 containing MYC, 13q22 containing KLF5/KLF12, 3q28 containing TP63, and 5p15 containing TERT. We detected 3p14 as a high-frequency HPV integration site in 4 cervical cancers. The gene discussed is KLF5; the disease is cervical cancer.