Currently, abnormal expression of LINC00460 had been found in many cancers, including nasopharyngeal carcinoma (50), esophageal squamous cell carcinoma (51), colorectal carcinoma (52–54), lung adenocarcinoma (49), non-small cell lung cancer (55–57), etc. Upregulated expression of LINC00460 predicted poorer differentiation, advanced stage, and worse overall survival (58). The gene discussed is LINC00460; the disease is esophageal squamous cell carcinoma.