To assess the expression of cell fusion-related proteins (GCM1, syncytin-1, and ASCT-2) and erythroid differentiation-related proteins (Hemoglobin-delta, Hemoglobin-zeta, CD71, GATA-1, and GATA-2) in human colorectal cancer tissues and their clinicopathological significance, IHC staining was performed on 180 samples of formalin-fixed and paraffin-embedded human colorectal cancer tissues, including well-differentiated (group I), moderately differentiated (group II), poorly differentiated colorectal cancer tissues (group III), and lymph node metastatic tissues (group IV). Here, HBD is linked to colorectal cancer.