Although pevonedistat may suppress the ability of dendritic cells to stimulate murine and human allogeneic T-cell responses [27], treatment with pevonedistat was shown to significantly inhibit infiltration of immune suppressor cells, including tumor-associated macrophages (TAMs) and myeloid derived suppressor cells (MDSCs), and promoted CD8 T cell infiltration in lung cancer models [28]. Here, CD8A is linked to neoplasm.