NHEJ inhibition by DNAPK inhibitors (NU7441 and NU7026) did not sensitize BL0479-72 to TMZ (Supplementary Figure 6E–6F) beyond the effect of the DNAPKi alone; therefore, the HR capacity of TMZ-sensitive and resistant bladder cancer lines was assessed using the DRGFP reporter [25]. The gene discussed is PRKDC; the disease is urinary bladder carcinoma.