The consequences of this research confirmed that the effect of miR-223 on the demonstration of MMP3 depended on the existence of STAT1, indicating that miR-223 mediated apoptosis and inflammation of NP cells by targeting JAK2/STAT1 and then promoted the degradation of intervertebral disc ECM and the occurrence of IDD. Here, JAK2 is linked to intervertebral disk degenerative disorder.