In this study, hepatocellular carcinoma cells were taken as the research objects, and the expression of miRNA-141 in hepatocellular carcinoma cells and the effect of targeting STAT4 on the proliferation, migration, and invasion of hepatocellular carcinoma cells were detected using qRT-PCR, MTT, and Transwell compartment method. Here, STAT4 is linked to hepatocellular carcinoma.