SMARCA4 RNA splicing defects, expression of particular microRNAs, signaling pathway activation such as PI3K or AKT have been shown to downregulate SMARCA4 expression in lung cancer, therefore, screening strategies that exclusively rely on next-generation sequencing may fail to detect lung cancers with nonmutational mechanisms of BRG1 inactivation (16). Here, SMARCA4 is linked to lung carcinoma.