To further verify the specific type of cells that express B7-H3 in the tumor microenvironment, we conducted HNSCC scRNA-seq using data from HNSCC-GSE103322 and HNSCC-GSE139324 via the TISCH website (TISCH, a scRNA-seq database, offers an extensive cell-type annotation at a single-cell level, which allows TME exploration across various kinds of cancer). Here, CD276 is linked to neoplasm.