Although an increase in splenic MIF expression paralleling the development of severe functional splenic in vitro GC insensitivity following two weeks of CSC exposure further suggests that MIF at least in part might be involved in mediating CSC-induced functional spleen changes, further studies are required as splenic MIF expression was decreased in CSC compared with SHC mice on day 20 of CSC despite pronounced splenomegaly and functional GC resistance. The gene discussed is MIF; the disease is Splenomegaly.