As above mentioned, RA-peptide shares sequence homology with proteins expressed by cells that are considered to be important in RA, such as Protein-tyrosine kinase 2 beta (PYK2/FADK2), B cell scaffold protein (BANK-1), Liprin-alpha 1 (LIPRIN-1), and Cytotoxic T-lymphocyte protein 4 (CTLA-4). This evidence concerns the gene PTK2B and rheumatoid arthritis.