Tim-1 deficiency resulted in an exacerbation of HFD-induced hepatic steatosis and inflammation, as evidenced by increased hepatocyte ballooning and excessive lipid accumulation concomitant with augmented infiltration of inflammatory cells as well as pronounced hepatic expression of LCN2 in HFD Tim-1-/- mice. Here, HAVCR1 is linked to Hepatic steatosis.