Results represented differential expression of 1310 lncRNAs and 743 mRNAs in NMO compared to the healthy group, which is related to IL23-mediated signaling events, IFN-g signaling, NF-κB signaling pathway, chemokine receptors, GPCR ligand binding, and metabolic disorders of biological oxidation enzyme pathways. This evidence concerns the gene IFNG and neuromyelitis optica.