AQP4-IgG1 was presented years before NMO diagnosis in SLE patients and correlated with the concentration of IFN-γ, CXCL10/IP-10, and CCL17/TARC. AQP4-IgG1, ANA, anti-dsDNA, and anti-nucleosome antibodies were increased during relapse. Autoantibody responses in NMO/SLE followed by Th1 responses. This evidence concerns the gene BTG3 and neuromyelitis optica.