Two main clusters were differentially expressed in NMO, namely, T-cell associated genes and NF-KB signaling genes. IL-7Ra was the most differentiated gene in the T-cell cluster that downregulated in patients. Furthermore, sIL7Ra and mIL7Ra isoforms were also lower in NMO especially AQP4+ samples. This evidence concerns the gene AQP4 and neuromyelitis optica.