- 46 SNPs were identified around the AQP4 gene- rs1964995 in the MHC region was the most associated SNP in NMO.- rs7186814 in chr 16 was associated SNP out of MHC region.- Three variants of MS risk were associated with NMO susceptibility. rs6677309 [CD58], rs1813375 [EOMES – CMC1], and rs694739 [PRDX5 – CCDC88B])- rs1516512 in the KCNMA1 was associated with EDSS and transverse myelitis. The gene discussed is PRDX5; the disease is neuromyelitis optica.