AQP4 and neuromyelitis optica: - 24 CNVs were significantly associated to NMO/NMOSD. They were mostly located on chr14.- A CNV deletion between 22,762,299 and 22,775,479 in TRA were prevalence in 13.27% of NMO.- Other CNVs were located on chr6 and 18.- Patients carrying CNVs tended to be AQP4-Ab-.