The CSF levels of IL-1 receptor antagonist, IL-6, IL-8, IL-13, IL-10, g-csf, and IP-10 were significantly higher in NMO, while only IL-6 level in serum has upregulation. CSF IL-6 level correlated with CSF cells and glial fibrillary acidic protein. The gene discussed is CXCL8; the disease is neuromyelitis optica.