Similar independent predictive characteristics were revealed for high TRIOQS-E in multivariable regression, including IF >20 (vs. IF <5, p = 0.034), phase II (vs. phase I, p = 0.021), specific cancer (lung cancer vs. pan cancer, p = 0.030; urinary system cancer vs. pan cancer, p = 0.013; other cancers vs. pan cancers, p = 0.012), certain kinds of immune checkpoint blocking agent (anti-PD-1, anti-PD-L1, and multiagents vs. anti-CTLA-4, all p < 0.001) (Table 4). The gene discussed is CD274; the disease is cancer.