NFKB1 and Granuloma: In contrast, other lung micro-environments could support granulomas with relatively few neutrophils but higher bacterial loads, such as those where the TNF threshold for NFkB activation is higher, the caseum levels required to shorten local neutrophil lifespan are greater, extracellular Mtb plays a smaller role in determining neutrophil directional movement, or neutrophils have reduced capacity to kill Mtb.