Interestingly, the ratio of tmTNF-α/sTNF-α was negatively correlated with the levels of proinflammatory mediators, including IL-1β, IL-6, and NO (Figures 4F, G), but was positively correlated with the level of the anti-inflammatory cytokine IL-10 (Figure 4H) in colonic tissues from mice with AOM/DSS-induced CAC. The gene discussed is IL1B; the disease is infectious otitis media.