CD4 and neoplasm: The number of CD4+CD17A+Th17 cells with proinflammatory and tumor-promoting effects increased slightly and peaked on day 19 in the spleen, but did not increase until day 70 in the mesenteric lymph nodes (Supplementary Figures S1C, D), while the number of Th17 cells in the colonic tissue was significantly enhanced on day 25 and peaked on day 70 (Supplementary Figure S1E).