The number of another type of immunosuppressive cell, CD4+CD25+Foxp3+Treg cells, increased in the spleen at all time points, except at the tumor stage (Supplementary Figure S1I), but the number of Treg cells increased during DSS drinking and returned to baseline levels in mesenteric lymph nodes during intervals between DSS consumption (Supplementary Figure S1J). Here, CD4 is linked to neoplasm.