A total of 146 patients with AE were enrolled, with 80 NMDAR antibody type, 36 LGI-1 antibody type and 30 other AE antibody type (AMPAR = 2, DPPX = 1, CASPR2 = 10, GABABR = 14, GAD = 2, GFAP = 1). The gene discussed is CNTNAP2; the disease is acrodermatitis enteropathica.