TGFB1 and Hepatic fibrosis: The results showed that the activation of HSCs into proliferative fibro/myo-fibroblasts has been found to be the central factor of liver fibrosis, and they found that the expression of α-SMA, a HSCs activation marker, and collagen I were increased after stimulating by TGF-β1 (Dewidar et al., 2019).