Although not rigorously explored, measurement of systemic biomarkers of sub-clinical inflammation such as the circulating neutrophil count, interleukin (IL)-6, and C-reactive protein (CRP) may help identify those at risk, while, as mentioned earlier, measurement of thyroid and antinuclear autoantibodies may also have predictive potential (Adegunsoye et al., 2015; Adegunsoye et al., 2017; Bonella et al., 2019; Buendía-Roldán et al., 2020). Here, CRP is linked to thyroid gland disorder.