TNF and rheumatoid arthritis: Previously, our group, combining the chemical and transcriptomic profiling, target prediction, network calculation, and experimental validations, identified the chemical constituents contained in BHGZD and revealed that BHGZD may ameliorate RA partially by restoring the balance of the “inflammation-immune” system and subsequently reversing the pathological events during RA progression through regulating the TLR4-c-Fos-IL2-TNF-alpha axis (Li W. et al., 2020), which was in line with the findings of other research groups (Li et al., 2017; Fang, 2018).