Accumulated studies have demonstrated that TLR4 initiates NLRP3 inflammasome–mediated pyroptosis (Chi et al., 2015; Martin-Rodriguez et al., 2015; Yin et al., 2020; X.; Zhang et al., 2020), which is a type of programmed cell death (Hersoug et al., 2018), largely involved in the pathogenesis of cell death, liver fibrosis (Wree et al., 2014), and chronic and acute inflammation (So et al., 2013; Zamyatina & Heine, 2020), such as RA (Guo et al., 2018; Li Z. et al., 2020; Pope & Tschopp, 2007; Shen et al., 2018; Wu et al., 2020). The gene discussed is TLR4; the disease is rheumatoid arthritis.