Especially, high expression levels of NLRP3 mRNA and NLRP3 inflammasome protein were observed in monocytes/macrophages, fibroblast-like synoviocytes (FLS), dendritic cells, and neutrophils from RA patients (Choulaki et al., 2015; Kim et al., 2017; Ruscitti et al., 2015;; Yang Z. et al., 2016). This evidence concerns the gene NLRP3 and rheumatoid arthritis.