IL6 and rheumatoid arthritis: RA at the active stage (active RA) is characterized by hyperactive immune response and excessive inflammatory cytokines (Mackiewicz, Schooltink, Heinrich, & Rose-John, 1992; ; Wang et al., 2012), including interleukin 1 (IL-1), interleukin 6 (IL-6), and interleukin 17 (IL-17) exerting their influences on both osteoclast differentiation and osteoblasts and active joint inflammation (Kawanaka et al., 2002; Dharmapatni et al., 2009; Karmakar et al., 2010).