LTF and central nervous system cancer: Furthermore, based on BSA NPs loading DOX and being modified with both lactoferrin (Lf) and mPEG2000, a dual-targeting drug delivery system was designed which could target the primary brain capillary endothelial cells (BCECs) and glioma cells (C6) and improve drug release efficiency, BBB penetration, and targeted antitumor properties (Su Z. et al., 2014).