C9 and amyotrophic lateral sclerosis: However, the proportion of those gene expression changes in C9 ALI-COs, which were also mutation-specific and overlapped with transcriptomic profiles from patients with ALS, were found to be the highest in astroglia and DLNs: 4.4% (8 out of 179 genes) and 4.3% (15 out of 316 genes), respectively (Fig. 3b–d, Extended Data Fig. 3a and Supplementary Fig. 3b).