PPP1R1B and non-small cell lung carcinoma: To test our hypothesis that DARPP-32 activates the PI3K signaling pathway in EGFR-mutated NSCLC cells, we used a bioinformatics approach to assess DARPP-32 transcript expression in specimens derived from 80 EGFR-mutated LUAD patients cataloged in The Cancer Genome Atlas (TCGA).