PPP1R1B and adenocarcinoma: DARPP-32, and its transcriptional splice variant t-DARPP, are frequently overexpressed in breast, gastric, thoracic, colon, pancreatic, and other adenocarcinomas, where their aberrant upregulation contributes to oncogenesis through regulation of cellular processes, including proliferation, survival, migration, and angiogenesis [31–39].