To test this hypothesis, we assessed the phosphorylation status of EGFR and ERBB3 proteins by immunoblotting in EGFR TKI-sensitive human NSCLC parental cells, HCC827 and PC9, overexpressing DARPP-32 or t-DARPP upon treatment with EGFR TKIs. The gene discussed is PPP1R1B; the disease is non-small cell lung carcinoma.